This is one of the big problems of medicine, and we are not close to solving it.
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And we are now close to exhausting it.
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To the extent that we are all writers in school and work, we are expected to stick close to nonfiction, which may partly explain why children tend to be more comfortable reading across the Dewey divide, not worrying if the beast is a tyrannosaurus or Hoppy Hopparoo.
And we are going to finally close the tax loopholes and stop giving tax breaks to companies that ship jobs overseas.
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"We have players in the squad who have had accidents from falling off roofs which have and they were given the choice but we are close-knit and wanted to do it as a team, " said Blake.
There is a vast variety of fresh, organically grown vegetables and fruits here, as we are close to the source.
And yet, we are no where close to being energy self-sufficient.
Supt Steve Fulcher, who is leading the investigation into the investigation for Wiltshire Police, said: We have made good progress in narrowing the search using a number of technologies and techniques and I believe we are getting very close to identifying Sian's whereabouts.
We give storytellers we have a relationship with more credibility than we give strangers, and stories that are close to us more weight than stories from foreign lands.
"Following careful consideration, we have announced that eight stores are proposed to close in the Northern Ireland region and we are working with those colleagues who are affected, " she added.
And it turns out that when the Earth is close to and zipping by the sun, when we are moving fastest in our annual orbit, that's the time of year we in the Northern Hemisphere call fall and winter.
Indeed, we do a pretty good job of selecting gifts for close friends and significant others people we are more likely to "get" and have some good reason for choosing the items we buy, notes Joel Waldfogel, an economist at the University of Minnesota.
And so he looks forward to that meeting because he believes we can do it and we are close.
We are very close and it could well come down to pivotal moments in the game.
Our civic, business and political cultures must be transformed if we are to close this gap.
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Over the next few months, we encourage the public to take a close look at the reforms we are considering and provide feedback.
We can actually reduce taxes and raise revenue -- a rare win-win -- if we are willing to close loopholes.
Already, there is a sense of 2005 revisited, and if my gut feeling is anything to go by, then we are all in for a thrilling and very close Test series.
But it also tells me we have to work even harder to close the gaps that still exist, and to uphold that simple American ideal: we are all equal and deserving of the chance to pursue our own version of happiness.
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And many jobs that we might once have thought of as being pretty close to heavy-duty combat, and which are often quite combat-oriented, are open to women, many of the piloting jobs, for example.
We can now fast-forward through commercials, black out banner ads and I suppose close our eyes when we drive past billboards (not recommended), and as such, companies are desperately trying to think of new ways to force feed us advertisements.
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And as I was saying earlier, it can't possibly be that the reforms to our tax code that were good and desirable then are somehow not worth doing now, that we shouldn't close those loopholes that allow corporations and wealthy individuals to take advantage of the tax code in a way that average folks can't.
We were eating with Raul Cabra and Michael Sledge, who are close to the Oaxacan food scene.
"We are now very close to a title sponsor and a second driver, " Adrian Campos told BBC Sport.
"We play a lot of close games, and these guys are used to it, " said Giants coach Bruce Bochy.
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This video illustrates how close we are to achieving "sense and avoid" capabilities that could satisfy aviation authorities around the world, if only for smaller UAVs at this stage.
The groups said that because of insecurity and funding difficulties, "we are precariously close, perhaps within weeks, to suspending some humanitarian support".
We are close to the realization of the smart home and the smart office, when we will never again have to walk into a dark room or a cold building.
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In none of the categories has it surpassed its relative valuation peak from 1980, but we are getting close compared to the median family income and the price of industrial metals.
We are exposed to and spread more information from our distant contacts than our close friends.
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