And Pompey had another escape when Aaron Mokoena diverted Corluka's cross towards his own goal, only to recover as Crouch closed in.
McCarthy has also teamed up with international colleague Aaron Mokoena at Rovers.
BBC: SPORT | Football | African | Striker McCarthy blasts Porto
City's winner came from a corner as Adebayor left his marker Aaron Mokoena and headed in Gareth Barry's inswinging delivery from close range.
Tal Ben-Haim had a powerful effort blocked by Howard's chest and then Aaron Mokoena's header hit the bar before Everton cleared off the line.
But European-based stars, including Mbulelo Mabizela and Aaron Mokoena, have been included for the Nelson Mandela Challenge showdown against Costa Rica in Potchefstroom on 11 October.
The second half was better for Portsmouth as Aaron Mokoena went close and Dave Kitson and Hayden Mullins forced fine saves from Barnet keeper Dean Brill.
Alves came on late in the game and powered a strike into the far corner after Aaron Mokoena had conceded the set piece with a foul on Ramires.
And the rout was complete when Aaron Mokoena laid on a sweet pass to fellow substitute Kanu, who rounded the beleaguered Simonsen before slotting home with nine minutes left.
Elsewhere, new South Africa captain Steven Pienaar , who replaced deposed Aaron Mokoena last week, is a big doubt for Saturday's critical Group G match at home to Egypt.
Former Tottenham midfielder Kevin-Prince Boateng pulled one back with a fierce shot from Steve Finnan's cross in the 59th minute, then Defoe saw red for a stamp on Aaron Mokoena two minutes later.
The former Manchester United striker was the difference - dropping deep to collect possession and influence his side's attacks and providing the moment of individual brilliance that gave Uruguay the lead midway through the first half via a 30-yard dipping shot that found the net via a glancing deflection off Aaron Mokoena.
应用推荐