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Hepatitis B is a similar liver disease that can range from a mild illness to a serious, chronic condition.
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Rothberg's 14-year-old daughter, the oldest of his five kids, has a mild form of an inherited disease called tuberous sclerosis complex, a relatively rare disorder (50, 000 or so Americans have it) that can cause benign tumors in the heart, kidney, skin, lungs, eyes and brain, where seizures can occur.
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And pre-specified secondary subgroup analyses of pooled data across both studies showed a statistically significant slowing of cognitive decline in patients with mild disease, but not in those with moderate disease.
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Meanwhile, the Allon Therapeutics drug helped improve some measures of short-term memory in patients with mild cognitive impairment, a condition that often leads to Alzheimer's disease.
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When it learned of these results Myriad switched its focus from cancer to Alzheimer's disease and began a trial of 210 men and women with mild to moderate Alzheimer's symptoms.
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Prof Robert Modlin, a dermatology and microbiology expert at the University of California, Los Angeles, said the study raises the possibility that a decrease or increase of one of these two proteins could shift the balance from mild to more serious disease.
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He adds he has heard from some people who have used the product even with mild cognitive symptoms but no diagnosis, or even a few with no symptoms but family histories of Alzheimer's disease.
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