为南瓜蛋白及其同类物的抗肿瘤机制提供理论基础,为肿瘤诱导分化疗法提供新线索。
To provide some theoretical foundation on anticancer mechanism of cucurmosin and its analogues, and provide a guide to differentiation-inducing therapy for cancer.
目的:观察肝损伤组织萃取物对人肝癌细胞株bel- 7402的影响,探讨肿瘤诱导分化治疗的新途径。
AIM: To observe the effects of tissue extracts of injured liver on BEL-7402 cells, and explore a novel strategy of tumor therapy by differentiation induction.
目的建立肿瘤细胞诱导分化的模型。
Objective To set up a cell model of human tumor cell inducing differentiation.
除了在局部免疫中发挥作用外,各种因素诱导产生的抗菌肽还参与细胞分化、组织修复及抗肿瘤等功能。
In addition to their role in immunity, some antibacterial peptides can play the distinct roles in cell differentiation, tissue repair and antitumor immunity.
目的:临床试验中对组蛋白脱乙酰基酶阻滞剂(HDACi)的研究目的在于诱导细胞分化,生长停止,和肿瘤细胞的凋亡。
Purpose: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells.
结论:ATRA并不能诱导HL-60细胞完成终端分化,但是该药可以诱导白血病细胞向成熟方向分化,而且已分化的肿瘤细胞于发生凋亡。
CONCLUSION: ATRA cannot induce HL 60 to achieve terminal differentiation, but the differentiation of HL 60 can be induced by ATRA and the differentiated leukemia cells are easy to apoptosis.
分化诱导剂被广泛应用于肿瘤的研究,在肿瘤的预防和治疗方面取得一定的进展,其中以维甲酸类药物效果肯定。
Agents that induce cell differentiation have been widely used in tumor research and achieved progress in the prevention and treatment of tumor. among them, retinoid drug shows confirmative effect.
结论:APS有可能成为既能促进正常造血,又能抑制白血病等肿瘤细胞增殖,并诱导其凋亡或分化的天然诱导剂。
Conclusion: APS may not only promote normal hematopoiesis, but also inhibit the proliferation of leukemia cell and it can be a natural inducer for therapy of malignant tumor.
目的肿瘤的诱导分化疗法是肿瘤治疗学研究的新领域。
Objectives the induction of differentiation therapy for cancer is a new field in the research of tumor treatment.
在捕获肿瘤抗原后,DC迁移至TDLN,发育成熟并递呈抗原,诱导T细胞分化、成熟,杀伤肿瘤细胞。
After capturing tumor antigen, DC migrates to TDLN where it becomes matured and starts presenting antigen, then induces t cell differentiation, maturation and to kill tumor cells.
目的:研究肿瘤细胞分化诱导剂尿多酸肽(CDA - II)对人胃癌细胞的体外抑制作用。
Objective: to study the inhibitory effect of Uroacitide (CDA-II) on human gastric cancer cell in vitro.
结论苯丁酸钠和其它诱导分化剂联合应用可能是部分血液肿瘤有效的诱导分化治疗方法。
Conclusion Phenylbutyrate combined with other differentiation agents may be an effective differentiation therapy in a proportion of hematological malignancies.
近年来,出现了诱导分化和凋亡等治疗手段,且在某些肿瘤的治疗上已取得了可喜的效果。
Recently, leading differentiation and apoptosis were found, and of a few clinical practice had proved their effect.
诱导分化是指在分化诱导剂的存在下,恶性肿瘤细胞的形态、生物学或生物化学方面的诸多标志均向正常细胞的方向分化,甚至完全转变成正常细胞。
By derived differentiation, we mean that under the effect of differentiation inducer, malignant tumor cell has the tendency to differentiate to normal cell, even became normal cells.
目的:研究小鼠骨髓干细胞体外诱导分化的树突状细胞对T细胞增殖的影响,为进一步研究树突状细胞的功能及临床肿瘤的治疗提供有效的实验方法。
Objective To study the effects of mature dendritic cells (DCs) derived from mouse bone marrow on T cell proliferation in vitro, and provide techinological methods for tumor therapy.
结论全反式维甲酸具有调控分化相关基因表达与否的重要作用,由RA诱导的肿瘤细胞再分化是一个多基因参与的过程。
Conclusion ATRA plays an important role in regulating the differentiation-related gene expression. ATRA-induced differentiation is a complex process with multiple genes involved.
目的 观察藤黄酸对肿瘤细胞的诱导分化作用。
Time effect on differentiation of neural stem cells to dopaminergic neurons;
目的 观察藤黄酸对肿瘤细胞的诱导分化作用。
Time effect on differentiation of neural stem cells to dopaminergic neurons;
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