特别地，在非蛋白质编码部分选择如何工作，选择丢弃什么样的变异：少数常见基因影响小或者许多罕见基因影响大？
In particular, how does it work on the non-protein-coding parts, and what kinds of variation does it leave behind: a few common genes with small effects or many rare genes with large effects?
这一细节让他们作出结论：可能是遗传获得的非编码DNA序列、而不是基因变异才使得最大部分的转录因子结合位置发生变化。
This detail led them to conclude that inherited non-coding DNA sequences – not mutations in genes – may drive the lion's share of differences in where transcription factors attach.
特别地，在非蛋白质编码部分选择如何工作，选择丢弃什么样的变异：少数常见基因影响小或者许多罕见基因影响大？
In particular how does it work on the non-protein-coding parts and what kinds of variation does it leave behind: a few common genes with small effects or many rare genes with large effects?
目的：分析43例中国人非综合征性听力减退（NSHI）患者的GJB2基因部分编码区的突变的情况。
Objective:To examine mutation in the partial coding region of GJB2 gene in 43 cases of Chinese patients with non syndromic hearing impairment (NSHI).
比较基因组学的研究发现： 人类基因组中约5%的序列受到选择压力的限制， 但编码序列只占其中很小一部分， 约3.5%是保守、非编码序列。
Study of comparative genomics has revealed that about 5% of the human genome are under purifying selection, 3.5% of which are conserved non-coding elements (CNEs).
比较基因组学的研究发现： 人类基因组中约5%的序列受到选择压力的限制， 但编码序列只占其中很小一部分， 约3.5%是保守、非编码序列。
Study of comparative genomics has revealed that about 5% of the human genome are under purifying selection, 3.5% of which are conserved non-coding elements (CNEs).
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